Predicting Gene Networks in Human Oocyte Meiosis
نویسندگان
چکیده
منابع مشابه
Predicting gene networks in human oocyte meiosis.
Meiosis is the characteristic feature of sexual reproduction; its molecular regulation has been preserved throughout eukaryotic evolution. The defining stage of meiosis is prophase I (Fig. 1), in which homologous chromosomes pair and remain tethered until the first meiotic division, when they must segregate equally into daughter cells that then enter meiosis II. The importance of this stage is ...
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Meiosis is one of the defining events in gametogenesis. Male and female germ cells both undergo one round of meiotic cell division during their development in order to reduce the ploidy of the gametes, and thereby maintain the ploidy of the species after fertilisation. However, there are some aspects of meiosis in the female germline, such as the prolonged arrest in dictyate, that appear to pre...
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Sirtuins have been implicated in diverse biological processes, including oxidative stress, energy metabolism, cell migration, and aging. Here, we employed Sirtuin inhibitors, nicotinamide (NAM) and Sirtinol, to investigate their effects on porcine oocyte maturation respectively. The rate of polar body extrusion in porcine oocytes decreased after treatment with NAM and Sirtinol, accompanied with...
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Progression through the meiotic cell cycle must be strictly regulated in oocytes to generate viable embryos and offspring. During mitosis, the kinesin motor protein Kif4 is indispensable for chromosome condensation and separation, midzone formation and cytokinesis. Additionally, the bioactivity of Kif4 is dependent on phosphorylation via Aurora Kinase B and Cdk1, which regulate Kif4 function th...
متن کاملChanges in gene expression associated with oocyte meiosis after Obox4 RNAi
OBJECTIVE Previously, we found that oocyte specific homeobox (Obox) 4 plays significant role in completion of meiosis specifically at meiosis I-meiosis II (MI-MII) transition. The purpose of this study was to determine the mechanism of action of Obox4 in oocyte maturation by evaluating downstream signal networking. METHODS The Obox4 dsRNA was prepared by in vitro transcription and microinject...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2010
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.109.083014